Since 1998, recommendations have been put forward in the USA and Europe for the management of accidental viral-risk exposure, namely through sexual transmission. According to the level of risk, these recommendations advise a standard 28-day post-exposure prophylaxis (PEP). This consists in a triple drug regimen including either three nucleoside analogs or a combination of two nucleoside analogs and a protease inhibitor. Certain guidelines also recommend standardized follow-up of PEP and HIV serostatus at least up to the third month following exposure (Almeda et al., 2004; Center for Disease Control [CDC], 2005; Fisher et al., 2006; Yeni, 2006).